The knockout stages of the champions league begin today [Wednesday] with Manchester United hosting Paris Saint-Germain and Porto going to Roma in the first leg of the round of 16 games.
Also on Thursday, Tottenham will host Bundesliga leader Borussia Dortmund.
Who's likely to start, who might be left out and who is unavailable? UEFA.com predicts all this week's line-ups.
Manchester United v Paris
Champions League round of 16 memorable moments
United: De Gea; Young, Lindelöf, Jones, Shaw; Herrera, Matić, Pogba; Lingard, Rashford, Martial
Out: Darmian (knock), Valencia (muscular)
Doubtful: none
Paris: Buffon; Kehrer, Thiago Silva, Kimpembe, Bernat; Marquinhos, Verratti; Dani Alves, Draxler, Di María; Mbappé
Out: Neymar (foot), Cavani (hip), Meunier (concussion)
Roma v Porto
Roma: Mirante; Florenzi, Manolas, Fazio, Kolarov; Pellegrini, De Rossi, Cristante; Zaniolo, Džeko, El Shaarawy
Out: Schick (thigh), Karsdorp (thigh)
Doubtful: Ünder (thigh), Perotti (calf), Olsen (calf)
Roma in training ahead of the Porto game
©Getty Images
Porto: Casillas; Éder Militão, Filipe, Pepe, Alex Telles; Danilo, Herrera, Óliver Torres; Otávio, Soares, Brahimi
Out: Marega (thigh), Corona (suspended)
Doubtful: none
WEDNESDAY
Tottenham v Dortmund
Tottenham: Lloris; Trippier, Sánchez, Alderweireld, Vertonghen; Winks, Sissoko, Eriksen; Lucas, Son, Lamela
Out: Kane (ankle), Alli (hamstring), Davies (groin)
Doubtful: Rose (shin)
Dele Alli and Harry Winks build their ultimate player
Dortmund: Bürki; Hakimi, Toprak, Diallo, Schmelzer; Witsel, Delaney; Sancho, Philipp, Guerreiro; Götze
Out: Alcácer (shoulder), Akanji (hip), Piszczek (foot), Reus (thigh), Weigl (illness)
Ajax v Real Madrid
Ajax: Onana; Mazraoui, De Ligt, Blind, Tagliafico; De Jong, Van de Beek, Schöne; Ziyech, Dolberg, Tadić
Out: Bandé (calf)
Doubtful: De Jong (groin), Tagliafico (knee), Magallán (leg)
Real Madrid: Courtois; Carvajal, Ramos, Varane, Reguilón; Modrić, Casemiro, Kroos; Bale, Benzema, Vinícius
Out: Isco (back), Llorente (adductor)
Doubt: Vallejo (hamstring)
All round of 16 fixtures kick off at 20:00GMT
uefa.com